berlin

K. Darrell Berlin, Ph.D.

Regents Professor

 413 Physical Sciences I

 405-744-5950

  kenneth.d.berlin@okstate.edu 

 

 

Education:

  • B.A., 1955, North Central College
  • Ph.D., 1958, University of Illinois

Postdoctoral Appointments:

  • WADC Postdoctoral Fellow, 1958-60, University of Florida

 Research Interests:

  • Organic synthetic methods
  • Medicinal chemistry
  • Heteroarotinoids as anti-cancer agents
  • Heterocycles
  • Organophosphorus chemistry
  • NMR analysis of dynamic systems

 

Our research efforts are focused upon synthesis.  The research involves the development of agents to treat a variety of cancers. The heteroarotinoid 1 (X = Y = S; Z = NO2) below has successfully passed all pre-clinical screening for the potential treatment of kidney and ovarian cancer.  Plans are to begin PHASE 0 and PHASE 1 clinical trials in 2018 involving humans. Research is continuing with the objective to synthesize modified versions of the clinical agent.

 

 

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